Web22 Dec 2024 · Zhang and colleagues analyzed patients with lung cancer treated with anti-PD-1 with single-cell methods, finding the presence of precursor exhausted T cells in responders that accumulated... Web9 Feb 2024 · This iteration of lineage tracing has the power to reveal how, when, and why precise metastatic events occur over the course of disease progression. It also sheds light on how we can better target the metastatic niche for drug development efforts. In this perspective, we highlight two technological advances: CRISPR-based lineage tracing and ...
9 A pan-cancer multi-omic immune single-cell atlas for cancer ...
Web30 Mar 2024 · Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8 + T cells are clonally linked to TCF7+ SELL+ progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8 + T, Treg, and TFH cells with proximity to the tumor microenvironment. Web1 Mar 2024 · In this way, the TCR serves as a molecular barcode that tracks processes such as migration, differentiation, and proliferation of T cells. Recent technological advances have enabled sequencing of the TCR from single cells alongside deep molecular phenotypes on an unprecedented scale. do you have to keep butter refrigerated
Temporal single-cell tracing reveals clonal revival and expansion …
Web23 Dec 2024 · Our data suggested that Texp cells were unlikely to be derived from the reinvigoration of terminally exhausted cells; instead, they were accumulated by (1) local expansion and (2) replenishment... Full Size Image - Temporal single-cell tracing reveals clonal revival and ... - Nature Web20 Jan 2024 · Temporal dynamics of T cells following PD-1 blockade Single-cell sequencing reveals temporal changes in tumor-infiltrating T cell populations before and … Web1 Jan 2024 · Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer January 2024 DOI: CC BY 4.0 … do you have to list multiple jobs on w4