site stats

Temporal single-cell tracing reveals clonal

Web22 Dec 2024 · Zhang and colleagues analyzed patients with lung cancer treated with anti-PD-1 with single-cell methods, finding the presence of precursor exhausted T cells in responders that accumulated... Web9 Feb 2024 · This iteration of lineage tracing has the power to reveal how, when, and why precise metastatic events occur over the course of disease progression. It also sheds light on how we can better target the metastatic niche for drug development efforts. In this perspective, we highlight two technological advances: CRISPR-based lineage tracing and ...

9 A pan-cancer multi-omic immune single-cell atlas for cancer ...

Web30 Mar 2024 · Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8 + T cells are clonally linked to TCF7+ SELL+ progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8 + T, Treg, and TFH cells with proximity to the tumor microenvironment. Web1 Mar 2024 · In this way, the TCR serves as a molecular barcode that tracks processes such as migration, differentiation, and proliferation of T cells. Recent technological advances have enabled sequencing of the TCR from single cells alongside deep molecular phenotypes on an unprecedented scale. do you have to keep butter refrigerated https://3dlights.net

Temporal single-cell tracing reveals clonal revival and expansion …

Web23 Dec 2024 · Our data suggested that Texp cells were unlikely to be derived from the reinvigoration of terminally exhausted cells; instead, they were accumulated by (1) local expansion and (2) replenishment... Full Size Image - Temporal single-cell tracing reveals clonal revival and ... - Nature Web20 Jan 2024 · Temporal dynamics of T cells following PD-1 blockade Single-cell sequencing reveals temporal changes in tumor-infiltrating T cell populations before and … Web1 Jan 2024 · Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer January 2024 DOI: CC BY 4.0 … do you have to list multiple jobs on w4

Articles in 2024 Nature Cancer

Category:Volume 3 Issue 1, January 2024 - Nature

Tags:Temporal single-cell tracing reveals clonal

Temporal single-cell tracing reveals clonal

Visualizing Clonal Evolution in Cancer: Molecular Cell

WebHere, we performed temporal single-cell RNA and paired T-cell receptor sequencing on 47 tumor biopsies from 36 patients with NSCLC following PD-1-based therapies. We … Web6. Liu B, et al. Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat Cancer 2024;3(1):108–121. 7. Bassez A, et al. A single-cell map of intratumoral changes during anti-PD1 treat-ment of patients with breast cancer. Nat Med 2024;27(5):820–832. 8.

Temporal single-cell tracing reveals clonal

Did you know?

Web22 Sep 2024 · Single-cell meta-analyses reveal responses of tumor-reactive CXCL13 T cells to immune-checkpoint blockade Request PDF Single-cell meta-analyses reveal responses of tumor-reactive CXCL13... Web13 Apr 2024 · As single-cell studies are extended to track temporal dynamics of T cells following PD-1 pathway blockade, patterns of treatment effects on tumor-reactive T cells in human tumors have begun to emerge. ... Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat ...

Web2 Jun 2016 · Clone evolution diagrams can capture temporal, phylogenetic, and, to some extent, spatial aspects of a tumor in a single static image. Their graphical presentation is … WebTemporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat Cancer 2024; 3 (1):108–121. 7. Bassez A, et al . A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer. Nat Med 2024; 27 (5):820–832.

WebAnti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood. Here, we performed temporal single-cell RNA and paired T-cell receptor sequencing on 47 tumor biopsies from 36 patients with NSCLC following PD-1-based … WebThe researchers performed temporal single-cell RNA and paired T-cell receptor sequencing on tumor biopsies from lung cancer patients following PD-1-based therapies, and …

Web24 Dec 2024 · Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Zhang and colleagues analyzed patients with lung cancer ... cleaning white sneakers in washing machineWeb10 Jun 2013 · It has recently been shown that splanchnic mesodermal precursors contribute to some lower jaw muscles , while extensive clonal analysis reveals common progenitors contributing to both extraocular and branchiomeric muscles . After migration into the BA core, myogenic progenitor cells leave the arches and move to their final positions within … cleaning white shoes with oxicleanWeb6 Apr 2024 · In clonal replacement, T cell clonotypes targeting the same neoantigen do not emerge simultaneously, but sequentially, with new clones identified after initial PD-1 … cleaning whites without bleach