PRM-151 is a novel investigational anti-fibrotic immunomodulator, a recombinant form of human pentraxin-2 (PTX-2) protein. For Roche, PRM-151, should it hit its developmental and regulatory milestones, will bolster the company’s existing IPF drug, Esbriet. WebMay 20, 2024 · The pentraxin protein family comprises three highly conserved plasma proteins synthesised by the liver and known to have pleiotropic properties. 1 Genetic deletion of serum amyloid P-component (SAP) has been associated with increased autoimmune response, fibrotic structural changes, and decreased clearance of apoptotic cells in vitro.
Roche Pipeline
WebParticipant Flow in a Trial of Recombinant Human Pentraxin 2 vs Placebo for Idiopathic Pulmonary Fibrosis View LargeDownload IPF indicates idiopathic pulmonary fibrosis. aRandomization ratio of 2:1 for recombinant human pentraxin 2 to placebo. bPatients receiving a stable dosage of pirfenidone or nintedanib. Figure 2. WebFeb 13, 2024 · PRM-151, a recombinant form of human pentraxin-2 (PTX-2) protein, opens up new opportunities to treat a wide range of systemic fibrotic diseases. Phase 2 trial results demonstrated that PRM-151... rainbow donuts menu
Clinical Trial – Idiopathic Pulmonary Fibrosis – Efficacy, Safety …
WebApr 11, 2024 · Pentraxin-2 is an endogenous human protein that plays an important role in regulating the response to fibrosis. It directs the immune system to naturally turn off and reverse the process of... WebMay 21, 2024 · rhPTX-2 is a recombinant form of human pentraxin-2, an endogenous protein that plays a critical beneficial role in fibrosis [17,18,19,20]. Plasma levels of pentraxin-2 have been found to be lower in patients with IPF compared with healthy age-matched controls . WebRecombinant human pentraxin-2 (rhPTX-2; PRM-151) has demonstrated clinical benefit in IPF patients in a phase II trial (NCT02550873). The STARSCAPE program includes a phase III 52-week pivotal, placebo controlled study ( NCT04552899 ) and a phase III open label extension (OLE) study ( NCT04594707 ). rainbow donuts diamond bar