Rbfox2是什么

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August undefined, 2024

WebOur analyses of Rbfox2 activity in mouse embryonic stem cells reveal hundreds of previously unknown splicing targets involved in diverse biological functions. In particular, we introduce a novel concept in splicing regulation whereby changes in the expression of one splicing factor induce a cascade of secondary and perhaps tertiary splicing changes … WebMay 5, 2024 · The RNA-binding protein RBFOX1 is an important regulator of neuron development and neuronal excitability. Rbfox1 is a dosage-sensitive gene and in both mice and humans, decreased expression of Rbfox1 has been linked to neurodevelopmental disorders. Alternative promoters drive expression of Rbfox1 transcript isoforms that …

The RNA-binding protein Rbfox2: an essential regulator of

WebOct 16, 2024 · However, RBFOX2-regulated RNA networks are not well defined. RBFOX2 has a well-characterized role in alternative splicing (AS) while accumulating evidence suggests that RBFOX2 may also have a role in alternative polyadenylation (APA). Recent studies showed that RBFOX2 binds to regions close to poly(A) sites in the 3’UTR of pre-mRNAs. WebMar 22, 2024 · Modulation of RBFOX2-regulated splicing events, such as via myosin phosphatase RHO-interacting protein (MPRIP), is associated with PDA metastases, altered cytoskeletal organization and the ... how fast are commercial airliners

CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast …

WebAug 1, 2024 · The intracellular localization of RBFOX2 protein differed with disease status, with RBFOX2 localized in the cytoplasm in calcific tendons and the nucleus in normal tendons. Analysis of the RBFOX2 protein-coding sequence showed that exon 10, responsible for nuclear localization, was absent in calcific tendons. WebSep 11, 2014 · With the goal of identifying splicing alterations in myotonic dystrophy 1 (DM1) tissues that may yield insights into targets or mechanisms, we have surveyed mis-splicing events in three systems using a RT-PCR screening and validation platform. First, a transgenic mouse model expressing CUG-repeats identified splicing alterations shared … WebNov 2, 2024 · RBFOX2-mediated APA modulates mRNA levels and/or isoform expression of a collection of genes, including contractile and mitochondrial genes. Depletion of RBFOX2 adversely affects mitochondrial health in myoblasts, correlating with disrupted APA of mitochondrial gene Slc25a4. high country releaf

RBFOX2 modulates a metastatic signature of alternative splicing in

RBFOX2 protein expression summary - The Human Protein Atlas

Rbfox2 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative splicing in the nervous system and other cell types. Rbfox2 and the related protein Rbfox1 bind to conserved (U)GCAUG RNA motifs in the introns adjacent to many alternatively spliced exons and promotes inclusion or exclusion of the alternative exon in mature transcripts. The protein also interacts with the estrog… WebNov 2, 2024 · RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing … high country renegades forumWebJun 16, 2016 · We isolated primary cardiomyocytes from WT and RBFox2 knockout heart by enzymatic perfusion and performed global nuclear run-on coupled with deep sequencing … how fast are comets

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Rbfox2是什么

WebMar 30, 2024 · Here, we employed both 3’-end and nanopore cDNA sequencing to reveal a previously unrecognized role for RBFOX2 in maintaining alternative polyadenylation (APA) signatures in myoblasts. We found that RBFOX2-mediated APA modulates both mRNA levels and isoform expression of a collection of genes including contractile and … WebFeb 27, 2014 · Here, we have used several established cell culture models to investigate the functions of Rbfox2 during EMT. We demonstrate that induction of an EMT upregulates …

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WebFeb 7, 2024 · INTRODUCTION. The RNA binding protein RBFOX2 has an emerging role in heart diseases ().Low RBFOX2 expression or activity are associated with heart failure and … WebRBFOX2-Binding Sites Are Enriched in Pre-mRNAs that Undergo AS Changes in Diabetic Hearts We have previously identiﬁed genome-wide AS changes in type 1 diabetic (T1D) mouse hearts with a corresponding in-crease in RBFOX2 protein levels (Verma et al., 2013). Therefore, we hypothesized that RBFOX2 is involved in AS dysregulation in diabetic hearts.

Web4.RBFox2与PRC2相互作用通过正反向CO-IP实验，作者验证了RBFox2与PRC2复合体多个成员相互作用，同时得到了Pull-down结果的支持。通过RBFox2截短体的构建，原核表达和 … WebMar 22, 2024 · Several studies have reported that RBFOX2 is upregulated, induces a mesenchymal splicing signature and promotes oncogenic splice-switching that drives an …

WebMar 21, 2024 · RBFOX2 (RNA Binding Fox-1 Homolog 2) is a Protein Coding gene. Diseases associated with RBFOX2 include Hypoplastic Left Heart Syndrome and Kaposi … WebJun 30, 2024 · 该研究通过转录组测序分析发现，受rbfox2和golim4-l调控的基因均富集于囊泡转运信号通路；细胞生物学实验结果表明，rbfox2和golim4-l可以通过影响高尔基体的稳定性，从而影响囊泡转运通路；进一步机制研究发现，golim4-l可以与囊泡转运相关蛋白rab26相互结合，招募其进入高尔基体中，共同维持高尔基 ...

Web尽管已经有很多研究表明RBFox蛋白在心脏疾病中的作用，但影响RBFox2表达的机制还需深入研究。. 目前，对RBFox蛋白功能与机制的研究多数是借助动物模型或人类病理组织中 …

WebCell Reports Article Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure Chaoliang Wei,1 Jinsong Qiu,1 Yu Zhou,1 Yuanchao Xue,1 Jing Hu,1 Kunfu Ouyang,2 Indroneal Banerjee,2 Caimei Zhang,4 Biyi Chen,4 Hairi Li,1 Ju Chen,2 Long-Sheng Song,4 and Xiang-Dong Fu1,3,* 1Department of Cellular … high country releaf dolores coWebMar 31, 2015 · G, immunoblot analysis of RBFOX2 protein levels in MCF7 cells expressing control and CLK2-targeting siRNAs. H, expression of CLK2 in MCF7 cells transfected with control or RBFOX2-targeting siRNAs. I, RT-PCR analysis of the levels of exon 11a ENAH splice isoforms in MCF7 cells following downregulation of RBFOX2. GAPDH was loaded … how fast are diesel trainsWebMay 5, 2024 · Background. Long noncoding RNAs (lncRNAs) play a significant role in the progression and metastasis of various cancers. LINC00893 has been reported to exert antitumor effect on various cancers such as gastric cancer and thyroid cancer. Bioinformatics analysis also predicted that LINC00893 was downregulated in colon … how fast are comets in mph how fast are corvettesWebJan 29, 2024 · Here, the authors demonstrate that splicing factor Rbfox2 is expressed in the neural crest cells (NCCs), and deletion of Rbfox2 in NCCs leads to cleft palate and defects … high country renegadesWebRBFOX2 (Homo sapiens). Target name RBFOX2. Target gene ID. GeneID:23543 high country rentals banner elkWebData and motif summary of RBP RBFOX2. Home; RBP > RBFOX2; RBP summary. RBP Name: RBFOX2 : RBP description: RNA Binding Fox-1 Homolog 2: UniProt ID: O43251: Entrez Gene: 23543: Species: Homo Sapiens: Protein domains: RRMx1: Subcellular localization (1 (nucleus) – 5 (cytoplasm): 2(HepG2) 2(HeLa) how fast are doberman pinschers