WebHeterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced by 14-3-3 proteins. WebDescription: Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA. RefSeq Summary (NM_004333): This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion.

Human Gene BRAF (ENST00000646891.2) from GENCODE V43

WebMay 7, 2024 · Hypertrophic cardiomyopathy is a common cause of mortality in congenital heart disease (CHD). Many gene abnormalities are associated with cardiac hypertrophy, … WebThe .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. college of patent agents and trademark agents

(PDF) Hypertrophic Cardiomyopathy in Noonan Syndrome

WebFeb 25, 2024 · Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left ventricular hypertrophy not solely explained by abnormal loading conditions. … WebApr 9, 2024 · Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality in children. While the aetiology is heterogeneous, most cases are caused by variants in the genes encoding components of the cardiac sarcomere, which are inherited as an autosomal dominant trait. In recent years, there has been a paradigm shift in the role of … WebNM_002880.4(RAF1):c.781C>A (p.Pro261Thr) AND Noonan syndrome Clinical significance: Pathogenic (Last evaluated: Apr 15, 2011) Review status: 1 star out of maximum of 4 stars college of paramedics small research grant