Ctgf tumor

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August undefined, 2024

WebJun 1, 2024 · Increasing evidence indicates that connective tissue growth factor (CTGF), a multifunctional signaling modulator, promotes cancer initiation, progression, and metastasis by regulating cell proliferation, migration, invasion, drug resistance, and epithelial–mesenchymal transition (EMT). CTGF is also involved in the tumor … WebJun 16, 2024 · FibroGen's pamrevlumab is a first-in-class antibody that inhibits the activity of connective tissue growth factor (CTGF), which, in cancer, is characterized by promotion of tumor growth.

CTGF Polyclonal Antibody (500-P252-1MG) - thermofisher.cn

WebAug 9, 2010 · MUC1 increases CTGF/CCN2 expression in pancreatic tumors cells. The MUC1.CT conducts signals from the cell surface by associating with and modifying the activity of transcriptional activators and ... WebApr 12, 2024 · Hepatic cancer is one of the deadliest malignancies throughout the world, ... The expression of CTGF, the most classical Hippo target gene, was used as the readout. (Fig. 1A). software 79

CTGF Mediates Tumor–Stroma Interactions between Hepatoma …

WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple … WebApr 20, 2016 · Breast cancer is the most common cancer in women worldwide, and approximately 90% of breast cancer deaths are the result of metastasis. Metastasis is the process by which tumor cells detach from a primary tumor and migrate to nearby blood vessels or the lymph system, and are thereby able to spread to other organs in the host … WebAug 8, 2024 · Lai, D., Ho, K. C., Hao, Y. & Yang, X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res ... slow cook machine

Epithelial derived CTGF promotes breast tumor progression via …

CTGF Mediates Tumor-Stroma Interactions between …

WebCTGF expression has been tied in with tumor growth, invasion, and metastasis. It shows aberrant expression in many forms of cancer, such as prostate, breast, and esophageal … WebJun 3, 2013 · Background The role of CTGF varies in different types of cancer. The purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). Experimental design CTGF expression levels were examined in NPC tissues and cells, nasopharynx (NP) tissues, and NP69 cells. The … software 81/08 gratisWebSep 1, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma … slow cook mac \\u0026 cheese

"WebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. " - Ctgf tumor

Ctgf tumor

Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity

WebSep 12, 2024 · INTRODUCTION. Urothelial bladder cancer (UBC) is a common urinary malignancy. In 2012, about 429,800 new cases and 165,100 deaths arising from UBC occur worldwide [].In the United States, UBC is estimated that to be the second most frequent genitourinary tract cancer and the fourth most common cancer in male in 2024 [].At … WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth …

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WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary … WebMay 10, 2024 · Our findings suggest that CTGF is a marker for medulloblastoma independent of molecular subgroups and its transcriptional program is active at the …

WebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …

WebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma. WebJul 27, 2024 · In this AM dataset, we annotated a new subcluster of fibroblasts, CTGF + CAFs, which might be a key factor in AM tumor occurrence and metastasis. CTGF + CAFs act on malignant cells …

WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... cancer, and infections. Glomerulonephritis is a common cause of end-stage renal failure. Severe and prolonged inflammation can …

WebElevated CTGF expression has been detected in many tumor types [5,17] where it has been identified as an invasion-specific gene [18] and is highly expressed within the neoplastic epithelium of PDAC [9]. Wenger et al. showed 59-fold enhancement of CTGF expression in 15 out of 19 samples of pancreatic tumors, compared with only 4.5-fold software 85108567WebAug 27, 2014 · (A) Fibroblasts were purified from Myc-CaP tumors 1 wk after sham operation or castration (C) (n = 10 per group), plated, and stimulated for 24 h with TGF-β1 (10 ng/mL), CTGF (50 ng/mL), or TGF-β1 plus CTGF. RNA was isolated, and expression of the indicated genes was analyzed as described earlier. software 7pmWebJun 6, 2012 · Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are … software 770/2023WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … slow cook mac \\u0026 cheese recipeWebFeb 28, 2024 · Results . AuNPs were able to decrease the density of colorectal cancer associated fibroblasts (CAFs), to reduce the production of tumor stromal collagen I, and to diminish the expression of profibrotic signals, including CTGF, TGF-β1 as well as VEGF in vivo and vitro via Akt signaling pathway. slow cook mac \u0026 cheeseWebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells and their signaling output mould the microenvironment to support tumorigenesis and metastasis [].In this context, cytokines, chemokines, as well as growth, angiogenesis and … software 770 2021WebJun 15, 2012 · Therefore, we investigated whether CTGF modulates metabolism in the tumor microenvironment. For this purpose, CTGF was overexpressed in normal human fibroblasts or MDA-MB-231 breast cancer cells. Overexpression of CTGF induces HIF-1α-dependent metabolic alterations, with the induction of autophagy/mitophagy, … software 8120