Cisplatin induced toxicity

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August undefined, 2024

WebFeb 11, 2024 · Mannitol for the prevention of cisplatin-induced nephrotoxicity: A retrospective comparison of hydration plus mannitol versus hydration alone in inpatient and outpatient regimens at a large academic medical center Show details Hide details Robert P Williams Brandon W Ferlas Paul C Morales Andy J Kurtzweil Journal of Oncology … WebApr 28, 2024 · Cisplatin-Induced Reproductive Toxicity and Oxidative Stress: Ameliorative Effect of Kinetin . Authors Rania Abdel-Latif 1 , Moustafa Fathy 2 , Hend Ali Anwar 2 , Muhammad Naseem 3 4 , Thomas Dandekar 4 , Eman M Othman 2 4 Affiliations 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Minia, …

Cisplatin nephrotoxicity - UpToDate

WebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is … WebJan 12, 2024 · Cisplatin has severe nonhematological toxicities, particularly nephrotoxicity and gastrointestinal toxicity. The recent development of new antiemetic therapies has greatly reduced... optix mag321cqr firmware

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WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebOct 26, 2005 · Cisplatin-induced cytotoxicity was determined by reduction of 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) as described previously ( Chen and Cederbaum, 1998 ). Measurement of intracellular GSH. Reduced glutathione (GSH) was assayed using a modified method of Hissin and Hilf (1976). WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研一站式 … optix mag301rf test

Nephrotoxicity and hydration management for cisplatin ... - PubMed

Induction of heme oxygenase-1 with hemin alleviates cisplatin …

WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin. WebA major problem besides cisplatin resistance (occurring in nearly one-third of patients) is the greater toxicity of the drug combinations. A synergistic treatment with drug supporting activity could maximize the cytotoxic effects of chemotherapeutic agents on tumor cells while decreasing the dosage of each drug to potentially reduce toxicity. optix mag27cq speakersWebIntroduction: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the treatment of many malignancies. Nephrotoxicity is the primary dose-limiting toxicity, and various hydration regimens and supplementation strategies are used to prevent cisplatin-induced kidney injury. porton down science park

"WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … " - Cisplatin induced toxicity

Cisplatin induced toxicity

Toxicity, risk factors and management of cisplatin …

WebFeb 16, 2016 · Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15–29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxicity (defined as … WebFeb 11, 2024 · Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our study was …

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WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 week) …

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebMay 18, 2024 · The overall incidence of cisplatin-induced renal toxicity in elderly patients is 10.06% (121/1203), which is significantly higher than that in young patients (6.51%, …

WebJun 21, 2024 · Sodium Thiosulfate and Cisplatin-Induced Hearing Loss Cisplatin is an effective treatment for hepatoblastoma but often leads to lifelong irreversible hearing … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …

WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects.

WebApr 25, 2014 · The use of cisplatin is frequently limited by various significant side effects such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity. After a single dose of cisplatin (50–100 mg/m2), approximately one-third of the patients develop nephrotoxicity [10, 11]. portooptimeringWebAug 9, 2024 · Cisplatin, despite its anti-cancer ability, exhibits severe testicular toxicities when applied systemically. Due to its wide application in cancer treatment, reduction of its damages to normal tissue is an imminent clinical need. portones chihuahuaWebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating toxicity. We aimed to address persistent knowledge gaps in CIHL by establishing benchmarks for the prevalence of and risk factors for CIHL. Methods portones de herreria sketchupWebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also activates apoptotic pathways and inflicts cellular damage via oxidative stress and inflammation. One of its dose limiting toxicities is its effects on the kidney. portopower sats redtool 10 tonWebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against … portophonvertragWebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in … portons knoxvilleWebOleuropein Ameliorates Cisplatin-induced Hematological Damages Via Restraining Oxidative Stress and DNA Injury Oleuropein Ameliorates Cisplatin-induced Hematological Damages Via Restraining Oxidative Stress and DNA Injury Indian J Hematol Blood Transfus. 2024 Sep;33 (3):348-354. doi: 10.1007/s12288-016-0718-3. … portopner windsor